The witnesses against Manafort include his former right-hand man, Rick Gates, a former Trump campaign aide who pleaded guilty to conspiracy and lying to the Federal Bureau of Investigation as part of a deal to cooperate with Mueller's office.
Already, Judge T.S. Ellis III has confronted questions about whether prospective jurors can be impartial in the highly charged case.
A pretrial hearing on the issue is slated for 9 a.m. (1300 GMT) on Tuesday, before jury selection begins. And they won't learn that Manafort's co-defendant in the Washington case is a business associate named Konstantin Kilimnik, who lives in Russia and who US authorities assert has connections to Russian intelligence.
None of the charges have any explicit connection to Russia's efforts to influence the 2016 election, and Manafort's lawyers had previously sought to dismiss the indictments against him.
Prosecutors also accuse him of lying to USA banks to obtain real estate loans in a bid to maintain a lavish lifestyle after his client, former pro-Russia Ukrainian president Viktor Yanukovych, fell from power in 2014 and the money stopped.
In a filing Monday, prosecutors responded that those details are necessary to prove how much money Manafort made and did not pay taxes on; that he knew he was paid through unreported foreign bank accounts; and that in 2014, he began committing bank fraud to make up for lost income from Ukraine.
Mueller has indicted a total of 32 people so far in connection with his probe into whether any members of Trump's election campaign colluded with Russian Federation to help get the NY real estate tycoon into the White House.
On Monday, prosecutors said in court filings that they meant to prove Manafort earned more than $60 million lobbying for the former pro-Russia Ukrainian government and failed to report "a significant percentage" of that.
Mueller's team says Manafort's position in the Trump campaign is relevant to some of the bank fraud charges. Manafort's wife, Kathleen, was sitting behind him in the courtroom.
Manafort actively conferred with his lawyers during the jury selection process, writing and passing notes.
What's likely to be missing: answers about whether the Trump campaign coordinated with the Kremlin during the 2016 presidential election, or really any mention of Russian Federation at all.
That task comes as the president and his lawyer-spokesperson, Rudy Giuliani, have intensified their attempts to undermine the Mueller investigation in the court of public opinion and as the US president continues to waffle on whether he'll sit for a private interview with prosecutors. Manafort worked on Trump's presidential campaign for five months and attended a June 2016 Trump Tower meeting with Russians that is a focal point of Mueller's probe into possible collusion between the campaign and the Kremlin.
"It seems to me we're seeing deeper ties that Manafort has had financially with his business deals in the Ukraine and with Russian Federation", said Shanlon Wu, a former lawyer for Manafort associate Rick Gates, who pleaded guilty in February and is aiding Mueller's probe.
Prosecutors have said they will not present evidence of collusion at this trial.
"I really hope the president continues to watch and make public comments about this case". The second trial, scheduled for September in the District of Columbia, involves allegations that he acted as an unregistered foreign agent for Ukrainian interests.
Manafort's attorneys have indicated that they no longer plan on arguing about the legitimacy of Mueller's appointment.