Patrick said earlier this week she had no regrets about her career, and that she doesn't think she will have the itch to come back.
Among other drivers who exited due to mishaps were three-time victor Helio Castroneves (lap 147) and 2013 victor Tony Kanaan (188).
"That guy was sitting here this morning before I walked in, sitting in his firesuit next to his engineer ready to go, about 6:30 this morning", Cindric said. And I don't know, maybe she's going to be fine.
Defending champion Takuma Sato also crashed out after running into the back of James Davison's auto.
Alexander Rossi was fourth, stealing a little of the spotlight along the way with a superb pass around the outside of Simon Pagenaud and Ryan Hunter-Reay to jump from fifth to third in one move, leaving Hunter-Reay to round out the top five.
The conditions created a slick, 2½-mile track, and new cars with less downforce proved to be a handful for even the most experienced of drivers.
Sebastien Bourdais was next, washing out in dirty air and walling it in Turn 4, followed not too long afterward by Helio Castroneves hitting the barrier in the same corner.
Patrick left IndyCar and moved on to stock cars in 2012, but never won a race.
Though Patrick's full-time racing career might be over, her time in the spotlight is not.
"I'm not really sure what happened", a dejected Patrick said after coming out of the care center.
It wasn't all celebration on the racetrack today, however, as Danica Patrick suffered a brutal crash earlier in the day. Power was working on reeling them in when both swerved into pitlane for fuel with three laps to go. Bourdais had led at least one lap in every race this season, and led for the first time in his career at Indianapolis. "When is the anthem?' But I had a lot of my people around me so I was in good spirits". The 30th-place finish was the worst of her career at the Indianapolis 500, a stark contrast to the six top-10s she produced in her previous seven starts from 2005-11.
As the race closed in on the halfway point Carpenter was the dominant auto on the track, but he was being seriously challenged by former Indy 500 victor Tony Kanaan.