That makes it now the fifth highest grossing film of all time worldwide, with room to carry on moving up the ranks.
Infinity War's $257 million (Rs 1700 crore) tally broke Star Wars: The Force Awakens' $248 million opening weekend record in the United States, and The Fate of the Furious' $540 million worldwide opening record with a huge $641 million (Rs 4300 crore) haul.
But past year, while promoting Guardians of the Galaxy Vol 2, Saldana referred to Avengers 4 as "Gauntlet" when talking to the BBC at the European premiere in London.
The $200 million opening in China is that nation's second-largest debut ever, behind only The Fate of the Furious. Count on it. Will it reach "Star Wars: The Force Awakens" at No. 3?
Coming from Feige, that could easily mean a whole lot of nothing, but the truth is that the MCU is going to need to introduce a new era of heroes to the world in order for it to move forward.
Disney broke records when the superhero film was first release late last month when its global opening drew about $640.9 million in sales. It now stands at the eight-largest all-time domestic release.
After amassing $61.8 million in domestic screens and $281.3 million from global markets in its third weekend, the running worldwide total of AIW now stands at a staggering $1.61 billion gross.
The leaker claimed: "The title was Avengers: Infinity Gauntlet at one point, but it might be changed after Zoe Saldana accidentally leaked it".
Domestic and worldwide together now puts "Avengers: Infinity War" at $1,606,829,103.
The Disney/Marvel blockbuster is now also the top film of 2018, surpassing Black Panther's earnings of $9.7 million.
2019 will also see the release of Captain Marvel and a sequel to Spider-Man: Homecoming and both films are expected to make close to $1 billion worldwide, according to a Forbes report. If it surpasses the lower end of the forecasted range, Deadpool will breaks its own record for the biggest domestic opener for an R-rated film.