Iniesta was given time and space to pick a pass and slid Rodrigo through on goal, the striker giving Hummels the slip and finishing well past Marc-Andre ter Stegen.
"We can learn a lot from tonight, that's why we wanted to play against teams like Spain and Brazil".
Said Loew: "Spain's best 11 to 13 players come from Atletico Madrid, Barca and Real Madrid, uniting all these virtues".
Spain dominated the early stages and opened the scoring in the sixth minute.
It was only a timely pounce by Ter Stegen that prevented a second Spanish goal in the 18th minute after Isco Alarcon controlled the ball with his chest to set up David Silva.
The cross-bar thwarted Mats Hummels' effort for Germany before late sub Diego Costa squandered the best opportunity of the night by delaying his shot just long enough for the German defence to regroup.
But as Germany gradually gained control the hosts levelled in stunning fashion in the 35th minute.
Mueller spotted Spain goalkeeper David de Gea off his line and unleashed a superb strike which hit the top left-hand corner from 20 yards out.
Only a great Ter Stegen save denied Isco, but the Germans counter-attacked immediately and De Gea had to palm away a shot by Gundogan.
There is also a start at right-back for Joshua Kimmich who has impressed at Bayern this season, ensuring both club and country have not missed the presence of Philipp Lahm.
There was little to choose between the two sides, who both demonstrated their quality and strength in depth and showed they will take some beating at this summer's Federation Internationale de Football Association 2018 World Cup.
Joao Miranda scored the opener in the 53rd minute, while Phillipe Coutinho made it 2-0 from the spot.
In the friendly with Die Mannschaft, both sides wasted big chances and the 29-year-old recognised the game could have gone either way but felt their were many positives to take.
"We were playing against the best team in the world now, a team with a lot of motivation and we've felt it".
"There are things to improve, but we know how good Germany are", he explained.