What may gall Mourinho the most will be that opposite number Vincenzo Montella's game plan is one the United manager has utilised to such good effect on so many occasions in the past. "We had a big game, as you know, against Liverpool and we came with high confidence to play this game, but Sevilla were better than us, so they deserved it".
"I don't want to make a drama of it".
Ben Yedder, a former futsal player for France, moved onto eight goals in this season's competition and he missed a chance for a hat trick as United's defense fell apart in the latter stages.
Porto and Real Madrid both knocked out United at Old Trafford under Mourinho's stewardship and the Portuguese was quick to highlight the club's previous failings after their shock exit. We have no time to be sad for more than 24 hours, that's football.
United finally worked a clear opening in the 38th minute, a powerful drive from Marouane Fellaini beaten away by Sergio Rico after Alexis Sanchez turned a one-two into the path of the Belgium global, who was making his first start of 2018. We scored that goal and then we did everything all together.
Ivan Ordets was sent off with 10 minutes to go for Shakhtar for a foul on Dzeko who was running through, making his team's bid for a goal to send them through harder.
Paul Pogba is another who has missed a number of fixtures with a small problem and Mourinho has admitted he still remains a doubt for the Champions League tie. He collected Pablo Sarabia's cross and cut past Marcus Rashford, only to be denied by a thumping Eric Bailly tackle.
Yet, the Belgian almost made the breakthrough with United's best move of the opening period when he latched onto Alexis Sanchez's layoff and his powerful effort was turned behind by Sergio Rico. "We are not the only team that invests money in players".
Mourinho responded by throwing on Anthony Martial and Juan Mata, but their attacking edge was needed far earlier as Ben Yedder soon put the outcome beyond any doubt when he forced home a corner at the far post despite a despairing effort by De Gea.
With the victory, the Spanish side have reached only their second ever European Cup quarter-final.