Stanford's Jon Alston had the previous best time for a linebacker in the 40, at 4.40 in 2006, the first year ESPN Stats & Information began documenting 40 times at the combine.
"So many people are going to have doubts about what I can do, and obviously, it started at the bench press", Griffin said Saturday.
The hand was amputated when he was four years old, the result of a rare condition known as amniotic band syndrome.
"People didn't think I'd be able to do it, and him just saying five (reps), I mean, five to me is just warming up", said Griffin, who used a black prosthetic device affixed to his left forearm. "I didn't know I had it in me, but it came out [Saturday]".
Shaquem Griffin's not concerned about his skills because he's proven that he can tackle and sack with precision, earning the title as the 2016 American Athletic Conference Defensive Player of the Year.
"Wow man. wow. I'm not going to get emotional on the phone, but it's an honor". We'll see how it goes [Sunday].
Shaquill Griffin actually did 17 repetitions in the bench press a year ago, but Shaquem will have a tall order to top his brother's 40-yard dash time.
Griffin's spotlight included doing 20 repetitions on the bench press while wearing a prosthetic, something the National Football League combine has never seen before. He said he expects to do both linebacker drills and defensive back drills, but said he would do both at his pro day if he is too worn out to do double duty Sunday.
Griffin, who played D-line, linebacker and safety at the Senior Bowl, said he's going to try to join the defensive back drills Sunday after doing his work with the linebackers. He consistently showed his speed to the ball, and numerous league's personnel evaluators said they believed he could contribute in an NFL defense, especially as a situational pass-rusher. Don't set limits for me, because when I wake up in the morning and I brush my teeth and I look at myself in the mirror, it's only me that I see in the mirror. Doesn't matter - I'm going to get it in, though.
"I would love to play with this guy!", Broncos linebacker Von Miller said on Twitter.