Clinically, this condition is called "compensated hypogonadism"-"hypogonadism" because the body probably isn't producing testosterone at the appropriate rate, and "compensated" because other hormones have kicked in and gotten testosterone levels to increase.
'In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased.
The other 17 men were administered a placebo and, within 14 days, those taking ibuprofen had developed the hormonal condition.
'Several studies have shown mild analgesics exposure during foetal life is associated with anti-androgenic effects and congenital malformations.
However, because the study is small, more research is needed to confirm the results.
The new study isn't the first to suggest that ibuprofen has downsides. Each dose was 600mg, equivalent to three over-the-counter pills. (In culture, there are no cells to produce luteinizing hormone to compensate.) The researchers found that a number of genes involved in steroid synthesis were affected by ibuprofen. The ibuprofen-poppers were instructed to take the recommended daily dosage limit of 1,200 mg day.
"Prescribing providers rarely mention these adverse effects with patients when prescribing these medications", she said, according to CNN, noting that the study was "important" and that the use of ibuprofen could have a far greater negative effect on men who already have low fertility. But researchers are concerned about long-term use among athletes.
"These compounds are good painkillers, but a certain amount of people in society use them without thinking of them as proper medicines", he added. "Taken together, these in vivo data suggest that ibuprofen induced a state of compensated hypogonadism during the trial..." the study states.
It's also not clear whether the same hormonal effects would be seen in men taking lower doses of ibuprofen, or whether the effects are reversible, particularly in men who take ibuprofen for long periods, study co-author Bernard Jégou, director of the National Institute for Research on Environmental and Occupational Health in France, told CNN.