"European states stressed their support for the JCPOA (aka nuclear deal) and condemned the remarks made by the US President Donald Trump".
"I don´t want to waste my time on answering the rants and whoppers of the brute U.S. president", Khamenei said in a speech to students in Tehran, published on his Telegram channel.
Trump's move put Washington at odds with other parties to the accord - Britain, France, Germany, Russia, China and the European Union - who say Washington can not unilaterally cancel an worldwide accord enshrined by a United Nations resolution.
"We will not tear the nuclear deal apart as long as the other side does not do so, but if they ripped it apart, we will shred it", he went on to say.
Earlier in the day, he said that the Trump announcement creates "an opportunity to fix the nuclear agreement and stop Iran's increasing aggression in our region", and suggested that every responsible government should take advantage of the announcement "in order to improve the agreement or abrogate it and, of course, stop Iran's aggression".
Tehran has said it is developing missiles exclusively for defensive purposes.
Trump's new program covers not just nuclear matters, but also Iran's missile program, support for terror, and regional aspirations that threaten the national security interests of the U.S. and its allies in the Middle East.
"They must avoid interfering in our defence programme", Khamenei said.
"While the U.S. government continuously is acting against the Iranian nation with imposing new sanctions and creating economic difficulties, against Iraqis and Syrians with growing terrorism, against Yemeni people with bombarding them, and against the people of Bahrain with supporting dictators, they label Iran as a supporter of terrorism without providing any evidence". Why do you have missiles yourselves?
Israel has been calling on Trump to "fix or nix" the Iran deal, and enthusiastically welcomed his move. "Why do YOU have nuclear weapons?" "We do not think it is acceptable for the Europeans to join America in its bullying".