The IRGC Commander's remarks came after the Financial Times reported that Trump is expected to designate IRGC as a terrorist organization next week as part of a new hardline strategy against the Islamic Republic.
Jafari rejected the idea of negotiating with Washington over regional issues and said if the U.S. designates the elite Revolutionary Guards Corps a terrorist group, it will in turn consider the United States military a terrorist group.
Speaking just before a meeting with top military brass, Trump vowed to "put an end to Iran's continued aggression and nuclear ambitions" and said a related announcement will be made "very shortly".
The head of the elite military unit also made a veiled threat to attack U.S. military bases in the region.
Should the United States carry out the so-called Countering America's Adversaries Through Sanctions Act (CAATSA), it will then have to relocate its regional bases out of the reach of Iran's missiles, which have a range of 2,000, Jaafari said at a high-profile IRGC session on Sunday.
Currently, U.S. military bases are located in countries neighboring Iran, including Bahrain, Iraq, Oman and Afghanistan, less than 500 kilometers (310 miles) from Iran's borders.
Trump's administration earlier this year considered, but then put on hold, adding the IRGC to the U.S. list of foreign terrorist organizations.
Revolutionary Guard forces are now fighting "Islamic State" (IS) militants in Syria and Iraq, and have suffered significant casualties as a result.
Jaafari cautioned the U.S. government of the dire consequences of imposing new sanction against Iran.
Jafari also warned the USA that a negative categorization of the Guard would eliminate "any chance for [bi-lateral] engagement forever".
The warning came after the White House said on Friday that President Donald Trump would announce new US responses to Iran's missile tests, support for what Washington calls Tehran's support for "terrorism" as part of his new Iran strategy.
The new Iran policy also follows reports that Trump will soon announce a decision to "de-certify" the landmark deal on Iran's nuclear program, opening the door for the re-implementation of crippling economic sanctions.