Huddersfield Town, on the other hand, have fared pretty well so far in their first top-flight campaign in 46 years.
Meanwhile, opponents Huddersfield are just two points behind Spurs in eighth spot, with nine points to their name.
The newly-promoted outfit beat Crystal Palace and Newcastle while recording draws with Southampton, Leicester City and Burnley.
David Wagner has been hit by injury problems in recent weeks and the Huddersfield boss is still without striker Steve Mounie, who remains sidelined with a heel issue. He had to miss their last couple of games but it could be very likely that he returns only after the worldwide break to be fit enough to start.
Harry Kane is the obvious pick in this market, but he doesn't provide much value for money at odds around 5/9.
In Depth: Forget the stats, Harry Kane is focusing on what matters most for Tottenham
Pochettino will welcome back Jan Vertonghen after he served a one-game suspension in the Champions League on Tuesday night so the Belgian global should make an immediate return at the back.
Harry Kane of Tottenham Hotspur celebrates scoring his sides second goal during the UEFA Champions League Group H match between Apoel Nicosia and Tottenham Hotspur at GSP Stadium on September 26, 2017 in Nicosia, Cyprus. Mousa Dembele's fitness continues to be worrisome and is unlikely to return in time for this game.
Having fully adopted the 3-4-2-1 as their preferred system, Spurs are as defensively sound as ever. The likes of Moussa Dembele, Erik Lamela, Victor Wanyama, and Danny Rose will also miss the game with respective injuries. This weekend, Kane will fancy his chances at some more goals as Spurs pay a visit to Huddersfield.
The Spurs equaled a record they had set in season 1960/61 after their Champions League victory over APOEL Nicosia that ensured that the visitors had won six successive away games. We have to play this card from the first whistle.
True, offers from Real Madrid or Barcelona could be tempting, but would Kane really be better off from a footballing perspective at another club in the Premier League?