Sterling K Brown won best dramatic actor for his role as an African- American adopted into a white family in NBC family drama, This Is Us.
She also used the awards ceremony to send a more overt message to two women - firstly her mother, whom she credited in her acceptance speech with being "brave and strong and smart".
"But now during the second season, we can open up and our periphery can expand beyond Gilead, which is going to be I think immensely rewarding for audiences and for our characters as well".
Archie Panjabi was the first British Asian actress to win an Emmy for outstanding supporting actress in 2010 for The Good Wife.
In the first major awards wins for streaming service Hulu, The Handmaid's Tale star Elisabeth Moss was named best drama actress for playing a woman forced into sexual servitude. "And that such an idea can be challenged today and that we can go back in time on these issues is scary". "It's what I'm most interested in as a woman, shows that are about women".
Television's glittering Emmys placed politics front and center on Sunday, lavishing "The Handmaid's Tale" with awards for its bleak portrait of an authoritarian America.
"However you feel about the president, and you do feel about the president, you can't deny that every show was influenced by Donald Trump in some way", he said.
Elsewhere in the comedy stakes, the 33-year-old Glover took home a brace of statuettes for directing and starring in the FX comedy series "Atlanta".
Julia Louis-Dreyfus won her sixth consecutive Emmy for playing an egotistical female presidential candidate on HBO's Veep.
HBO's "Big Little Lies" was the night's other big victor.