It takes 83 minutes for a signal from the spacecraft to reach Earth, so we'll recieve final pics and data later in the afternoon.
The Cassini mission represents more than one generation of work at NASA and ESA, with development beginning in the 1980s. This last route took Cassini in the gap between Saturn and its rings, the closest the vehicle has ever come to the planet.
Safe disposal of Cassini was seen as the best way to avoid the remote possibility of contaminating the pristine moons with Earth bugs.
While telescopes will be pointed at Saturn to try and capture Cassini's last moments, it likely will be moving too fast (and is too small) for any images.
On its final orbit, Cassini will plunge into Saturn's atmosphere at tens of thousands of miles per hour, sending back new and unique science to the very end.
Earl Maize, Cassini's project manager, said: "The signal from the spacecraft has gone, and within 45 seconds so will the spacecraft". What we'll watch it is slowly turn away from us and we'll watch the indicator on the radio science displays that will go down flat and essentially lost signal.
Cassini moved closer to its demise Monday by zipping past Saturn's moon Titan, a pass that shifted the spacecraft's trajectory and sent it on a path into Saturn's atmosphere - a close encounter called a "goodbye kiss".
"So we're here today to cheer as Cassini finishes that race", she said. Perhaps most tantalizing, ocean worlds were unveiled by Cassini and its hitchhiking companion, the Huygens lander, on the moons Enceladus and Titan, which could possibly harbor life.
Now, it's used up all its fuel, according to a NASA statement, and in order to ensure researchers can study the area without interruption in future, Cassini must undertake a final suicide run, leaving the path clear for future craft. So what's next? There's plenty to look forward to, including the ARRM Asteroid Redirect mission, Europa Clipper to Jupiter's icy, potentially life-supporting Europa moon and the Mars 2020 Rover mission, to name just a few. The image was taken by NASA's Cassini spacecraft on September 13, 2017.
Cassini departed Earth in 1997 and arrived at the sixth planet from our sun in 2004.
It burned through 183 main engines but was able to collect more than 453,000 images and travel 4.9 billion miles. Nothing from Earth has landed farther. It was an global endeavor, with 27 nations taking part.