The Briton was out-of-sorts in a subdued performance on Sunday as the Latvian broke her seven times to seal a 6-4, 7-5 fourth-round win, in what was an error-strewn match for both players.
"I didn't play the tennis level that I maybe would have liked to have played, but I competed the best I could". "Mentally I'm spent. Totally spent".
Anastasija Sevastova and Caroline Wozniacki meet in the quarterfinals of the 2016 US Open. Three in a row still gave the edge to Sevastova but once more Konta pushed her hard.
But the Latvian regained her composure in time to hold serve and then break Konta, who was appearing in the last 16 for the second consecutive year, to clinch victory.
All in all it was a disappointing display from Konta against a woman who retired from tennis in 2013 for almost two years due to a series of injuries.
12 breaks of serve in the match told there own story but it was Sevastova's superior shotmaking that proved the crucial factor as she saw off Konta to go with her second round victory over French Open champion Garbine Muguruza.
"In the end I just stop thinking and I just try to play tennis", Sevastova said. Sevastova added: "I had too many injuries".
The Latvian now moves into a quarterfinal matchup with the victor of American Madison Keys and Denmark's Caroline Wozniacki.
"I felt I did the best I could today", said Konta. "Because if I'm not in the top five, I feel like it's not where I want to be, so at that point, whether I'm 20 in the world or 100 in the world, it doesn't matter because I'm going to play the same people anyway".
Next up for Vinci is the victor between second-seeded Australian Open champion Angelique Kerber and 14th-seeded twice Wimbledon champion Petra Kvitova. The Brit quickly went to 0-40, though was once again pulled back and ended up facing another match point, though Sevastova missed her return and Konta was able to hold on for 5-5.
Fatigue may have played a part - she admitted she was still recovering from her on-court collapse in the second round - but it was the British number one's usually reliable ground shots that cost her dear. 30 winners, 26 unforced errors. It seemed that the Latvian could finally breakthrough when she hit a victor to start, and cross court forehand passing shot to set up a third match point proved to be crucial, with Sevastova finally progressing after the Brit made a final forehand error.